Research Area 2: Generic technology platforms for producing novel and/or improved vaccines
Malignant catarrhal fever (MCF) is an important bovine viral infection with high mortality rates. There is no spesific treatment or prevention method either curing or controlling the disease. The infection is caused by a group of herpesviruses from the family of Herpesviridae. The MCF subgroup of Macaviruses, called MCFV, contains at least 10 members and five of which are currently known to cause disease. With in these etiological agents two major groups is outstanding; the Alcelaphinae/Hippotraginae group and the Caprinae group. The two most important viruses are ovine herpesvirus 2 (OvHV-2), which causes sheep-associated MCF and Alcelaphine herpesvirus 1 (AlHV-1), which is endemic in
wildebeest populations worldwide causing wildebeest-associated MCF; and , and is endemic in most sheep populations worldwide. Caprine-associated MCF: caprine herpesvirus 2 (CpHV-2): endemic in most domesticated goat populations worldwide and causes MCF in cervids. A new inactivated virus vaccine, prepared with an innovative adjuvant, contains an effective option to control the disease effectively by activating the immune response of susceptible animals.
Çukurova University Faculty of Ceyhan Veterinary Medicine is working on novel vaccines development and together with Faculty of Fisheries for novel bio-adjuvants development. There is currently running 3 patent applications on these field. The research laboratories and field experiences are highly qualified. The resaerch team would like to be a partner at novel vaccine and adjuvant researches under this ICRAD call.