DNA vaccines, LentiDNA, non-integrative viral DNA, T cell based vaccines
Research Area 2: Generic technology platforms for producing novel and/or improved vaccines
We have developed a lentiDNA technology that helps to use the properties of DNA vaccines and those of lentivirus vectors but without their drawbacks. We found that the HIV prototype has an increased immunogenicity in both the mouse and non-human primate (macaque) models. We found that this prototype was a powerful inducer of a variety of vaccine-specific CD4+ and CD8+ T cells including memory precursors, central memory and effector cells. These responses were composed of multifunctional long lasting T cells associated with a powerful homeostasis upon restimulation with the antigen. These responses were associated with efficacious control of pathogenic replication competent virus in absence of neutralizing antibody responses. In this EraNet research project we are seeking partners for a consortium that will develop and study the efficacy of veterinary lentiDNA prototypes against viral diseases in livestock animals such as avian influenza, bovine herpes infections, retroviral infections in ruminants,... Please feel free to contact me for any further discussion.
PAVAL Lab., is a joint unit of the National Institute of Agronomic and Environment Research (INRAE) and the University Grenoble Alpes (UGA) located in the main campus of UGA. The lab has supports from both institutions and is well equipped to conduct all experimental studies in Molecular and cellular Biology, in silico, ex vivo and in vivo studies.